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Through systematic fractionation of human albumin, Pickart and colleagues isolated a small peptide responsible for the difference, eventually identifying it as a three-amino-acid sequence glycine, histidine, and lysine with an unusually strong affinity for binding copper(II) ions

The maintenance of optimal reduced/oxidized ratios within cell compartments is crucial for healthy cellular redox 45 , and disruption caused by high concentrations of these substances could explain the observed adverse effects on cell viability